I think I'm logged into the wrong account, but I am the same one who started the thread. Anyway, I figured out the issue. My machine was set to stay on, but had to swap out for another that went to sleep. After waking from sleep, the Host service will not restart on it's own. So Sophos had nothing to do with it.
Restarting the service would fix it until the machine goes back to sleep. I could remotely wake from another machine on the network and then remote in and restart service. Waking the machine alone wouldn't fix it.